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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Gene Ontology (automatically populated)
molecular_function (GO:0003674)
binding (GO:0005488)
 protein binding (GO:0005515
transcription regulator activity (GO:0030528)
 transcription repressor activity (GO:0016564
cellular_component (GO:0005575)
organelle (GO:0043226)
membrane-bounded organelle (GO:0043227)
intracellular membrane-bounded organelle (GO:0043231)
 nucleus (GO:0005634
biological_process (GO:0008150)
biological regulation (GO:0065007)
regulation of biological process (GO:0050789)
regulation of cellular process (GO:0050794)
regulation of gene expression (GO:0010468)
regulation of transcription (GO:0045449)
regulation of transcription, DNA-dependent (GO:0006355)
 negative regulation of transcription, DNA-dependent (GO:0045892
 CategoryGO term IDTermEvidencePubmed
1BPGO:0045892negative regulation of transcription, DNA-dependentIPI12444977
2CCGO:0005634nucleusIC12444977
3MFGO:0005515protein bindingIPI12444977
4MFGO:0016564transcription repressor activityIPI12444977
MeSH cloud (automatically populated)
About this section
The MeSH cloud below displays MeSH terms that are associated with this transcription factor. The physical size of the terms reflect the significance of their association with the transcription factor as determined by the Fisher's Exact Test. It should be noted that these associations do not necessarily imply a positive correlation between the described MeSH term and this transcription factor. For instance, if the MeSH term "apoptosis" occurs, it may indicate that this transcription factor can induce apoptosis (positive correlation), or prevent apoptosis (negative correlation). Methods: The transcription factor is mapped to a set of Pubmed publications through the gene-to-pubmed association as provided by NCBI. Then, a collection of MeSH terms associated with the papers are compiled, along with the frequency of each MeSH term. The Fisher's Exact Test is conducted on the frequency of each term in the collection, versus its average frequency, to determine its significance in the collection. More information on MeSH can be found on the MeSH homepage.
MeSH term Fisher's exact p-value
1 DNA, Complementary 1.0 x 10-17
2 Gene Library 2.5 x 10-16
3 Zinc Fingers 3.2 x 10-15
4 Mice, Inbred C57BL 1.0 x 10-12
5 Transcription, Genetic 4.6 x 10-11
6 COS Cells 5.6 x 10-8
7 Ikaros Transcription Factor 1.0 x 10-7
8 Expressed Sequence Tags 1.6 x 10-7
9 Genomics 2.0 x 10-7
10 Repressor Proteins 2.0 x 10-7
11 Chondrocytes 3.2 x 10-7
12 Chondrogenesis 2.7 x 10-6
13 Mice, Knockout 3.3 x 10-6
14 Transcription Initiation Site 3.5 x 10-6
15 Chromosome Breakage 4.8 x 10-6
16 DNA Primers 1.2 x 10-5
17 Hair Follicle 1.2 x 10-5
18 Chromosome Inversion 1.6 x 10-5
19 Growth Plate 1.6 x 10-5
20 Conserved Sequence 2.1 x 10-5
21 Crosses, Genetic 3.5 x 10-5
22 Neoplasm Proteins 4.0 x 10-5
23 Quantitative Trait Loci 4.9 x 10-5
24 Two-Hybrid System Techniques 9.0 x 10-5
25 Cytoplasmic Dyneins 0.00013
26 Mutagenesis, Insertional 0.00018
27 RNA, Messenger, Stored 0.00018
28 Protein Structure, Tertiary 0.00036
29 Blastula 0.00037
30 Blastocyst 0.00041
31 Growth Differentiation Factor 5 0.00043
32 Sequence Homology, Amino Acid 0.00049
33 Xenopus laevis 0.00051
34 Homeodomain Proteins 0.00061
35 Osteochondrodysplasias 0.00062
36 Sequence Analysis, DNA 0.00076
37 Cercopithecus aethiops 0.00076
38 Bone Morphogenetic Protein Receptors, Type I 0.00078
39 RNA, Antisense 0.00089
40 Transfection 0.00092
41 GATA4 Transcription Factor 0.0010
42 Tetraodontiformes 0.0011
43 Multifactorial Inheritance 0.0011
44 Ciona intestinalis 0.0011
45 Organ Specificity 0.0015
46 Algal Proteins 0.0017
47 Core Binding Factor Alpha 1 Subunit 0.0019
48 Hypertrichosis 0.0020
49 Gene Expression Regulation, Developmental 0.0022
50 Image Cytometry 0.0023
51 Gene Expression Profiling 0.0025
52 Terminator Regions, Genetic 0.0026
53 Models, Genetic 0.0028
54 Protein Binding 0.0029
55 Sequence Tagged Sites 0.0030
56 Vibrissae 0.0031
57 Regulatory Sequences, Ribonucleic Acid 0.0032
58 RNA Caps 0.0032
59 Cell Differentiation 0.0033
60 Alopecia Areata 0.0034
61 Epistasis, Genetic 0.0039
62 Parathyroid Hormone-Related Protein 0.0043
63 Chromatin Immunoprecipitation 0.0048
64 Databases, Nucleic Acid 0.0050
65 Pulmonary Diffusing Capacity 0.0050
66 POU Domain Factors 0.0051
67 RNA Stability 0.0051
68 Neocortex 0.0055
69 Sp1 Transcription Factor 0.0058
70 Cell Proliferation 0.0058
71 Abnormalities, Multiple 0.0064
72 3' Untranslated Regions 0.0073
73 Chromosomes, Human, Pair 8 0.0073
74 STAT3 Transcription Factor 0.0073
75 Retroelements 0.0088
76 Xenopus Proteins 0.0090
77 Lod Score 0.0092
78 Animals, Newborn 0.0097
79 Lung Compliance 0.010
80 Bacteriophage lambda 0.010
81 Plasmids 0.010
82 Promoter Regions, Genetic 0.010
83 Eukaryotic Cells 0.011
84 High Mobility Group Proteins 0.012
85 Schistosoma mansoni 0.013
86 Gene Targeting 0.014
87 Bone Morphogenetic Proteins 0.015
88 Proteome 0.016
89 Body Patterning 0.017
90 Templates, Genetic 0.017
91 p38 Mitogen-Activated Protein Kinases 0.017
92 Mutation, Missense 0.020
93 Electrophoresis, Capillary 0.020
94 Genome, Human 0.021
95 RNA Interference 0.022
96 Mesoderm 0.022
97 Alternative Splicing 0.024
98 Luciferases 0.024
99 Gene Rearrangement 0.025
100 beta-Galactosidase 0.027
101 User-Computer Interface 0.031
102 Open Reading Frames 0.031
103 Major Histocompatibility Complex 0.032
104 Glutathione Transferase 0.032
105 Total Lung Capacity 0.034
106 Age of Onset 0.034
107 Introns 0.034
108 Respiratory Mucosa 0.036
109 Microsatellite Repeats 0.039
110 Reproducibility of Results 0.040
111 Genes, Reporter 0.040
112 Loss of Heterozygosity 0.040
113 Haplotypes 0.040
114 Transcriptional Activation 0.041
115 3T3 Cells 0.044
116 Microscopy, Confocal 0.044
117 In Situ Hybridization, Fluorescence 0.046
118 Mice, Inbred C3H 0.047
119 Embryonic Development 0.049
120 Multigene Family 0.049
MeSH term Fisher's exact p-value
1 Mice 1.2 x 10-39
2 GATA Transcription Factors 2.4 x 10-31
3 Murinae 7.5 x 10-29
4 Muridae 2.4 x 10-28
5 Rodentia 9.9 x 10-28
6 Genetic Phenomena 2.4 x 10-26
7 Genetic Structures 1.0 x 10-25
8 Genetic Techniques 1.8 x 10-23
9 Transcription Factors 1.9 x 10-22
10 Nucleic Acid Probes 4.5 x 10-20
11 Molecular Probes 6.0 x 10-20
12 DNA-Binding Proteins 6.2 x 10-20
13 DNA Probes 3.1 x 10-19
14 Genome 8.7 x 10-19
15 Molecular Structure 1.9 x 10-18
16 DNA, Complementary 1.0 x 10-17
17 DNA, Single-Stranded 5.8 x 10-17
18 Amino Acid Motifs 1.6 x 10-16
19 Gene Library 2.5 x 10-16
20 Genetic Processes 4.8 x 10-16
21 Zinc Fingers 3.2 x 10-15
22 Laboratory Chemicals 1.1 x 10-13
23 Protein Structure, Secondary 1.3 x 10-13
24 Genome Components 2.7 x 10-13
25 Biochemical Phenomena 4.6 x 10-13
26 Animal Population Groups 6.8 x 10-13
27 Gene Expression 9.4 x 10-13
28 Mice, Inbred C57BL 1.0 x 10-12
29 Mice, Inbred Strains 5.0 x 10-12
30 Molecular Sequence Data 2.2 x 10-11
31 Documentation 4.2 x 10-11
32 Chemical Phenomena 4.4 x 10-11
33 Transcription, Genetic 4.6 x 10-11
34 DNA 6.1 x 10-11
35 Information Services 8.2 x 10-11
36 Nucleic Acids, Nucleotides, and Nucleosides 1.3 x 10-10
37 Protein Conformation 1.5 x 10-10
38 Nucleic Acids 1.5 x 10-10
39 Gene Expression Regulation 2.0 x 10-10
40 Base Sequence 2.3 x 10-10
41 Computational Biology 2.6 x 10-10
42 Kruppel-Like Transcription Factors 3.7 x 10-10
43 Gene Components 6.3 x 10-10
44 Chromosome Mapping 9.0 x 10-10
45 Specialty Uses of Chemicals 9.5 x 10-10
46 Molecular Conformation 2.6 x 10-9
47 Animals, Inbred Strains 2.7 x 10-9
48 Animals, Laboratory 3.1 x 10-9
49 Cloning, Molecular 6.9 x 10-9
50 Genes 1.2 x 10-8
51 RNA, Messenger 2.2 x 10-8
52 Mice, Transgenic 2.5 x 10-8
53 Nuclear Proteins 2.7 x 10-8
54 Animals, Genetically Modified 4.4 x 10-8
55 COS Cells 5.6 x 10-8
56 Information Science 6.0 x 10-8
57 Mutation 6.9 x 10-8
58 Biochemical Processes 7.7 x 10-8
59 Organisms, Genetically Modified 9.5 x 10-8
60 Ikaros Transcription Factor 1.0 x 10-7
61 In Situ Hybridization 1.2 x 10-7
62 Expressed Sequence Tags 1.6 x 10-7
63 Genomics 2.0 x 10-7
64 Repressor Proteins 2.0 x 10-7
65 Chondrocytes 3.2 x 10-7
66 Phenotype 3.6 x 10-7
67 Cell Line, Transformed 5.2 x 10-7
68 Genetic Variation 7.2 x 10-7
69 Chemical Processes 1.1 x 10-6
70 RNA 1.2 x 10-6
71 Mice, Mutant Strains 2.5 x 10-6
72 Chondrogenesis 2.7 x 10-6
73 Mice, Knockout 3.3 x 10-6
74 Transcription Initiation Site 3.5 x 10-6
75 Staining and Labeling 3.7 x 10-6
76 Proteins 3.7 x 10-6
77 Cells 4.5 x 10-6
78 Chromosome Breakage 4.8 x 10-6
79 Embryo, Mammalian 5.5 x 10-6
80 Biology 6.2 x 10-6
81 Nucleic Acid Hybridization 6.5 x 10-6
82 Mutagenesis 8.2 x 10-6
83 Connective Tissue Cells 1.0 x 10-5
84 DNA Primers 1.2 x 10-5
85 Hair Follicle 1.2 x 10-5
86 Chromosomes, Mammalian 1.4 x 10-5
87 DNA Breaks 1.5 x 10-5
88 Chromosome Inversion 1.6 x 10-5
89 Sequence Inversion 1.6 x 10-5
90 Growth Plate 1.6 x 10-5
91 Histocytological Preparation Techniques 1.7 x 10-5
92 Embryonic Structures 1.7 x 10-5
93 Genetic Loci 1.8 x 10-5
94 Conserved Sequence 2.1 x 10-5
95 Oligodeoxyribonucleotides 2.8 x 10-5
96 Amino Acids, Peptides, and Proteins 3.2 x 10-5
97 Morphogenesis 3.3 x 10-5
98 Crosses, Genetic 3.5 x 10-5
99 Neoplasm Proteins 4.0 x 10-5
100 Amino Acid Sequence 4.8 x 10-5
101 Quantitative Trait Loci 4.9 x 10-5
102 Mammals 5.0 x 10-5
103 Bone and Bones 5.5 x 10-5
104 Genetics 6.2 x 10-5
105 Growth and Development 6.5 x 10-5
106 Databases, Factual 6.6 x 10-5
107 Fibroblasts 7.7 x 10-5
108 Oligonucleotides 7.9 x 10-5
109 Polymerase Chain Reaction 8.7 x 10-5
110 Organogenesis 8.9 x 10-5
111 Two-Hybrid System Techniques 9.0 x 10-5
112 Nucleic Acid Amplification Techniques 9.2 x 10-5
113 Vertebrates 9.3 x 10-5
114 Epiphyses 9.4 x 10-5
115 Chordata 9.4 x 10-5
116 Bone Diseases, Developmental 0.00012
117 Cytoplasmic Dyneins 0.00013
118 Databases as Topic 0.00013
119 Polynucleotides 0.00013
120 Embryonic and Fetal Development 0.00015
121 Mutagenesis, Insertional 0.00018
122 RNA, Messenger, Stored 0.00018
123 Cell Line 0.00018
124 Cells, Cultured 0.00018
125 Skeleton 0.00020
126 Information Storage and Retrieval 0.00021
127 Animals 0.00024
128 Chemical Actions and Uses 0.00027
129 Biological Science Disciplines 0.00034
130 Genotype 0.00035
131 Chromosomes 0.00036
132 Databases, Genetic 0.00036
133 Protein Structure, Tertiary 0.00036
134 Blastula 0.00037
135 Investigative Techniques 0.00038
136 Protein Interaction Mapping 0.00039
137 Blastocyst 0.00041
138 Hair Diseases 0.00042
139 Growth Differentiation Factor 5 0.00043
140 Epidermis 0.00046
141 Sequence Homology, Amino Acid 0.00049
142 Xenopus laevis 0.00051
143 Eukaryota 0.00054
144 Homeodomain Proteins 0.00061
145 Osteochondrodysplasias 0.00062
146 Regulatory Elements, Transcriptional 0.00067
147 Hair 0.00074
148 Sequence Analysis, DNA 0.00076
149 Cercopithecus aethiops 0.00076
150 Nucleotides 0.00078
151 Bone Morphogenetic Protein Receptors, Type I 0.00078
152 Cercopithecus 0.00080
153 RNA Splicing 0.00088
154 RNA, Antisense 0.00089
155 Regulatory Sequences, Nucleic Acid 0.00089
156 Transfection 0.00092
157 Models, Biological 0.00097
158 GATA4 Transcription Factor 0.0010
159 Information Systems 0.0010
160 Tetraodontiformes 0.0011
161 Multifactorial Inheritance 0.0011
162 Ciona intestinalis 0.0011
163 RNA Processing, Post-Transcriptional 0.0014
164 Sequence Homology 0.0014
165 Xenopus 0.0015
166 Pipidae 0.0015
167 Organ Specificity 0.0015
168 Gene Transfer Techniques 0.0017
169 Algal Proteins 0.0017
170 Bone Morphogenetic Protein Receptors 0.0017
171 Cellular Structures 0.0017
172 Inheritance Patterns 0.0018
173 Core Binding Factor Alpha 1 Subunit 0.0019
174 Cytological Techniques 0.0019
175 Hypertrichosis 0.0020
176 Antisense Elements (Genetics) 0.0021
177 RNA, Untranslated 0.0021
178 DNA, Intergenic 0.0022
179 Gene Expression Regulation, Developmental 0.0022
180 Musculoskeletal Development 0.0023
181 Image Cytometry 0.0023
182 Histological Techniques 0.0025
183 Gene Expression Profiling 0.0025
184 Growth Differentiation Factors 0.0025
185 Skin 0.0025
186 Terminator Regions, Genetic 0.0026
187 Sequence Analysis 0.0028
188 Models, Genetic 0.0028
189 Protein Binding 0.0029
190 Sequence Tagged Sites 0.0030
191 Vibrissae 0.0031
192 Regulatory Sequences, Ribonucleic Acid 0.0032
193 RNA Caps 0.0032
194 Cell Nucleus 0.0032
195 Cell Differentiation 0.0033
196 Alopecia Areata 0.0034
197 Connective Tissue 0.0035
198 Integumentary System 0.0036
199 DNA Damage 0.0038
200 Recombination, Genetic 0.0039
201 Epistasis, Genetic 0.0039
202 Urochordata 0.0042
203 Parathyroid Hormone-Related Protein 0.0043
204 Dyneins 0.0044
205 Core Binding Factor alpha Subunits 0.0046
206 Core Binding Factors 0.0048
207 Chromatin Immunoprecipitation 0.0048
208 Databases, Nucleic Acid 0.0050
209 Pulmonary Diffusing Capacity 0.0050
210 POU Domain Factors 0.0051
211 RNA Stability 0.0051
212 Physiological Processes 0.0052
213 Neocortex 0.0055
214 Sp1 Transcription Factor 0.0058
215 Cell Proliferation 0.0058
216 Medical Informatics Applications 0.0060
217 Cell Growth Processes 0.0060
218 Sp Transcription Factors 0.0061
219 Medical Informatics 0.0062
220 Musculoskeletal System 0.0064
221 Abnormalities, Multiple 0.0064
222 Chordata, Nonvertebrate 0.0065
223 Embryo, Nonmammalian 0.0070
224 3' Untranslated Regions 0.0073
225 Chromosomes, Human, Pair 8 0.0073
226 STAT3 Transcription Factor 0.0073
227 Anura 0.0076
228 Immunoprecipitation 0.0080
229 Repetitive Sequences, Nucleic Acid 0.0082
230 Protein Engineering 0.0086
231 Retroelements 0.0088
232 Xenopus Proteins 0.0090
233 Lod Score 0.0092
234 Animals, Newborn 0.0097
235 Amphibians 0.0097
236 Cell Physiological Processes 0.0097
237 Cercopithecinae 0.0098
238 Cercopithecidae 0.0099
239 Lung Compliance 0.010
240 Amphibian Proteins 0.010
241 Bacteriophage lambda 0.010
242 Plasmids 0.010
243 Siphoviridae 0.010
244 Natural Science Disciplines 0.010
245 Promoter Regions, Genetic 0.010
246 Clinical Laboratory Techniques 0.011
247 Eukaryotic Cells 0.011
248 High Mobility Group Proteins 0.012
249 Schistosoma mansoni 0.013
250 Untranslated Regions 0.014
251 Gene Targeting 0.014
252 Bone Morphogenetic Proteins 0.015
253 Alopecia 0.015
254 Hypotrichosis 0.015
255 Chromosome Aberrations 0.016
256 STAT Transcription Factors 0.016
257 Models, Theoretical 0.016
258 Proteome 0.016
259 Caudovirales 0.017
260 Body Patterning 0.017
261 Metabolism 0.017
262 Templates, Genetic 0.017
263 p38 Mitogen-Activated Protein Kinases 0.017
264 Genetic Engineering 0.019
265 Bone Diseases 0.019
266 Mutation, Missense 0.020
267 Electrophoresis, Capillary 0.020
268 Organelles 0.021
269 Schistosoma 0.021
270 Schistosomatidae 0.021
271 Genome, Human 0.021
272 RNA Interference 0.022
273 Mesoderm 0.022
274 Alternative Splicing 0.024
275 Luciferases 0.024
276 Gene Rearrangement 0.025
277 Cell Physiological Phenomena 0.025
278 Chromosomal Proteins, Non-Histone 0.025
279 Protein-Serine-Threonine Kinases 0.026
280 beta-Galactosidase 0.027
281 Pulmonary Gas Exchange 0.028
282 Congenital Abnormalities 0.028
283 Germ Layers 0.029
284 Cytoplasmic Structures 0.030
285 User-Computer Interface 0.031
286 Open Reading Frames 0.031
287 Physiological Phenomena 0.032
288 Reading Frames 0.032
289 Major Histocompatibility Complex 0.032
290 Glutathione Transferase 0.032
291 Total Lung Capacity 0.034
292 Age of Onset 0.034
293 Introns 0.034
294 Animal Structures 0.036
295 Respiratory Mucosa 0.036
296 Metabolic Phenomena 0.036
297 Galactosidases 0.037
298 Gene Silencing 0.037
299 Trematoda 0.037
300 Molecular Motor Proteins 0.038
301 Microsatellite Repeats 0.039
302 Interspersed Repetitive Sequences 0.040
303 Reproducibility of Results 0.040
304 Genes, Reporter 0.040
305 Loss of Heterozygosity 0.040
306 Haplotypes 0.040
307 Allelic Imbalance 0.040
308 Transcriptional Activation 0.041
309 Cytoplasm 0.041
310 Alkyl and Aryl Transferases 0.043
311 3T3 Cells 0.044
312 Microscopy, Confocal 0.044
313 Lung Volume Measurements 0.044
314 In Situ Hybridization, Fluorescence 0.046
315 Mice, Inbred C3H 0.047
316 Epithelium 0.047
317 Coliphages 0.047
318 Growth 0.047
319 Embryonic Development 0.049
320 Multigene Family 0.049
 3' Untranslated Regions   3T3 Cells   Abnormalities, Multiple   Age of Onset   Algal Proteins   Alopecia Areata   Alternative Splicing   Animals, Newborn   Bacteriophage lambda   beta-Galactosidase   Blastocyst   Blastula   Body Patterning   Bone Morphogenetic Protein Receptors, Type I   Bone Morphogenetic Proteins   Cell Differentiation   Cell Proliferation   Cercopithecus aethiops   Chondrocytes   Chondrogenesis   Chromatin Immunoprecipitation   Chromosome Breakage   Chromosome Inversion   Chromosomes, Human, Pair 8   Ciona intestinalis   Conserved Sequence   Core Binding Factor Alpha 1 Subunit   COS Cells   Crosses, Genetic   Cytoplasmic Dyneins   Databases, Nucleic Acid   DNA Primers   DNA, Complementary   Electrophoresis, Capillary   Embryonic Development   Epistasis, Genetic   Eukaryotic Cells   Expressed Sequence Tags   GATA4 Transcription Factor   Gene Expression Profiling   Gene Expression Regulation, Developmental   Gene Library   Gene Rearrangement   Gene Targeting   Genes, Reporter   Genome, Human   Genomics   Glutathione Transferase   Growth Differentiation Factor 5   Growth Plate   Hair Follicle   Haplotypes   High Mobility Group Proteins   Homeodomain Proteins   Hypertrichosis   Ikaros Transcription Factor   Image Cytometry   In Situ Hybridization, Fluorescence   Introns   Lod Score   Loss of Heterozygosity   Luciferases   Lung Compliance   Major Histocompatibility Complex   Mesoderm   Mice, Inbred C3H   Mice, Inbred C57BL   Mice, Knockout   Microsatellite Repeats   Microscopy, Confocal   Models, Genetic   Multifactorial Inheritance   Multigene Family   Mutagenesis, Insertional   Mutation, Missense   Neocortex   Neoplasm Proteins   Open Reading Frames   Organ Specificity   Osteochondrodysplasias   p38 Mitogen-Activated Protein Kinases   Parathyroid Hormone-Related Protein   Plasmids   POU Domain Factors   Promoter Regions, Genetic   Protein Binding   Protein Structure, Tertiary   Proteome   Pulmonary Diffusing Capacity   Quantitative Trait Loci   Regulatory Sequences, Ribonucleic Acid   Repressor Proteins   Reproducibility of Results   Respiratory Mucosa   Retroelements   RNA Caps   RNA Interference   RNA Stability   RNA, Antisense   RNA, Messenger, Stored   Schistosoma mansoni   Sequence Analysis, DNA   Sequence Homology, Amino Acid   Sequence Tagged Sites   Sp1 Transcription Factor   STAT3 Transcription Factor   Templates, Genetic   Terminator Regions, Genetic   Tetraodontiformes   Total Lung Capacity   Transcription Initiation Site   Transcription, Genetic   Transcriptional Activation   Transfection   Two-Hybrid System Techniques   User-Computer Interface   Vibrissae   Xenopus laevis   Xenopus Proteins   Zinc Fingers