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The article completion score is designed to help authors identify parts of their articles that can be expanded upon. We highly recommend completing the following steps to significantly increase this article's score: Please submit more binding sites to Pazar to generate a binding site profile for the TFBS tab. Please add more papers to the Papers tab. Please add a few more targets to the Targets (author curated) section of the Targets tab. Please add a few more interactors to the Interactions (author curated) section of the Interactions tab. Please provide more information in the Overview section of the Summary tab. Please provide more information in the Covalent modifications section of the Protein tab. Please provide more information in the Overview section of the Structure tab. If applicable, please provide more information in the Isoforms section of the Protein tab. Please provide more information in the Overview section of the TFBS tab. Please provide more information in the Overview section of the Interactions tab. Please provide more information in the Overview section of the Targets tab. Please indicate which papers should be considered as important or preferred in the Papers tab. Comments (post) There are no comments posted here... Yet. Overview No annotation is available in this section for this article. The content below is taken from a related TF, TBR1 (Homo sapiens). TBR1 (T-Brain-1), EOMES (Eomesodermin), and TBX21 together form the TBR1 subfamily of T-box genes in vertebrates (see review by Naiche et al., 2005, in Papers tab)[1]. EOMES is also known as TBR2; TBX21 is also known as T-BET. T-box genes are also found in invertebrate animals, but not outside the animal kingdom. However, TBR1 subfamily genes are not present in Drosophila or C. elegans. Like other members of the T-box family (17 in mammals), TBR1 subfamily genes are mainly important for development and differentiation of specific cell types in various organs. Expression mapping and targeted mutations in mice have revealed both overlapping and non-overlapping roles for Tbr1 subfamily genes in the development of brain, eye, immune system, mesoderm, and placenta. Examples of specific functions mediated by TBR1 family genes include the following. Eomes and Tbr1 implement a program of glutamatergic neuronal differentiation in developing mouse brain (Hevner et al., Neurosci. Res., 2006)[2]. Tbx21 activates the program of Th1 differentiation in T-cells, and represses Th2 fate (Szabo et al., Cell, 2000)[3]. Indeed, Tbx21 and Eomes are critical regulators in a number of immune cell types (Glimcher et al., Nat. Rev. Immunol., 2004)[4]. In contrast to the fascinating phenotypes in mice, much less is known about TBR1 subfamily functions in humans. Only EOMES has been linked to a specific human disorder, severely affecting the brain (see Baala et al., 2007, in Papers tab)[5]. Frogs and zebrafish have also been important model systems for studying these genes, which have been identified in many vertebrates. Insights into the evolution of the TBR1 subfamily have come from studies in Amphioxus, where a single orthologous gene is expressed (Horton and Gibson-Brown, J. Exp. Zool., 2002)[6]. References
Figures No annotation is available in this section for this article. The content below is taken from a related TF, TBR1 (Homo sapiens).
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