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Overview

Since HNF4α was first identified as a factor that bound DNA response elements in the promoter region of liver-specific genes, many target genes were quickly identified for HNF4α in the liver using classical promoter deletion techniques. Those genes encode many of the proteins involved in intermediary metabolism, as well as those involved in blood maintenance, such as blood coagulation factors (F8, F9, F10, etc.). Point mutations in some of the blood coagulation gene promoters, as well as the HNF1A promoter, lead to human diseases such as hemophilia and diabetes, respectively. The human hepatitis B virus promoter/enhancer regions are also targets for HNF4α which is required for viral propagation. Only a few HNF4α target genes in the other tissues (pancreas, kidney, small intestine, colon) have been identified by classical means.

Recent studies using genome-wide techniques (such as Chip-chip and expression profiling) have identified more than a thousand additional potential targets of HNF4α, although it remains to be determined how many of those are direct targets resulting from a specific HNF4α-DNA interaction.

Genome-wide target papers:

ChIP-chip or ChIP-seq

  • [1] - Odom DT et al, 2007 (primary mouse, human hepatocytes)
  • [2] - Odom DT et al, 2004 (primary human hepatocytes, beta cells)
  • [3] - Odom DT et al, 2006 (primary human hepatocytes)
  • [4] - Rada-Iglesias A et al, 2005 (HepG2, human hepatocyte)
  • [5] - Wallerman O et al, 2009 (HepG2, human hepatocyte)
  • [6] - Boyd M et al, 2009 (CaCo2, human colon)
  • [7] - Schmidt D et al, 2010 (human, mouse, dog, opossum and chicken liver)

Transcription profiling

  • [8] - Naiki T et al, 2002 (HuH-7, human hepatocyte)
  • [9] - Lucas B et al, 2005 (HEK293, human embryonic kidney)
  • [10] - Waxman DJ et al, 2006 (rat liver)
  • [11] - Garrison WD et al, 2006 (mouse colon)
  • [12] - Gupta RK et al, 2007 (mouse beta cells)
  • [13] - Erdmann S et al, 2007 (INS1, rat beta cells)
  • [14] - Ishikawa F et al, 2008 (NMuMG, mouse mammary epithelial)
  • [15] - Grigo K et al, 2008 (HEK293, human embryonic kidney)
  • [16] - Battle MA et al, 2006 (mouse liver)
  • [17] - Yuan X, Ta TC et al, 2009 (HCT116, human colon)
  • [18] - Boj SF et al, 2009 (human and mouse, liver)
  • [19] - Darsigny M et al, 2009 (mouse, colon)
  • [20] - Bolotin E et al, 2010 (HepG2, human hepatocyte)

Listed in the tables below (both the author-curated and automatically populated from PAZAR) are just those target genes that have been verified by classical techniques (i.e., gel shifts, luciferase assays). Please see the genome-wide papers cited above for additional potential HNF4a target genes.

HNF4 Motif Finder allows identification of additional potential target genes by searching for experimentally verified and computationally predicted binding motifs in a DNA sequence of interest.

Targets (author curated)
  Target gene TF complex Effect References GO terms (biological process)
1 ABCC2 (human) HNF4a
(unknown)
19010343 2 terms found
2 ADAMTS1 (human) hnf4a
(unknown)
18163890 6 terms found
3 ALDH6A1 (human) hnf4a
(unknown)
18163890 7 terms found
4 ANK3 (human) hnf4a
(unknown)
18163890 2 terms found
5 BPHL (human) hnf4a
(unknown)
18163890 2 terms found
6 CDKN1A (human) hnf4a
(unknown)
18163890 30 terms found
7 CYP2C8 (human) HNF4a
(unknown)
15933212 5 terms found
8 Dio1 (mouse) HNF4A
(unknown)
18426912 2 terms found
9 DSC2 (human) hnf4a
(unknown)
18163890 2 terms found
10 EFHD1 (human) HNF4A
(unknown)
18163890 1 terms found
11 EPHX2 (human) hnf4a
(unknown)
18163890 10 terms found
12 EPS15L1 (human) HNF4A
(unknown)
18395097 1 terms found
13 Eps15l1 (mouse) HNF4A
(unknown)
18395097 1 terms found
14 FIGF (human) HNF4a
(unknown)
18199540 8 terms found
15 GHR (human) HNF4A
(unknown)
17991764 38 terms found
response to interleukin-1   growth hormone receptor signaling pathway (IMP, 7565946)   cartilage development involved in endochondral bone morphogenesis   response to glucocorticoid stimulus   positive regulation of peptidyl-tyrosine phosphorylation   insulin-like growth factor receptor signaling pathway (IMP, 7565946)   response to cycloheximide (IDA, 9360546)   creatinine metabolic process   positive regulation of JAK-STAT cascade   positive regulation of cell differentiation   multicellular organismal metabolic process (IMP, 8137822)   neuroprotection   response to peptide hormone stimulus   response to morphine   activation of JAK2 kinase activity   positive regulation of tyrosine phosphorylation of Stat5 protein (ISS, 2825030)   positive regulation of tyrosine phosphorylation of Stat3 protein (ISS, 2825030)   positive regulation of multicellular organism growth (IMP, 2813379)   regulation of multicellular organism growth   cellular response to hormone stimulus (IMP, 7565946)   cellular response to insulin stimulus   response to estradiol stimulus (IDA, 12552091)   response to food   receptor internalization (IDA, 9360546)   taurine metabolic process   hormone-mediated signaling pathway   JAK-STAT cascade   endocytosis   fatty acid metabolic process   creatine metabolic process   valine metabolic process   isoleucine metabolic process   oxaloacetate metabolic process   succinate metabolic process   2-oxoglutarate metabolic process   citrate metabolic process   allantoin metabolic process   activation of MAPK activity  
16 MME (human) hnf4a
(unknown)
18163890 3 terms found
17 NELL2 (human) HNF4A
(unknown)
18163890 2 terms found
18 Nr1h4 (mouse) HNF4A
(unknown)
14729567 9 terms found
19 NR1I2 (human) HNF4A
(unknown)
18305375 9 terms found
20 Nr2f2 (mouse) HNF4a
(unknown)
18474611 13 terms found
21 PROS1 (human) HNF4A
(unknown)
18163890 1 terms found
22 PROZ (human) hnf4a
(unknown)
17958743 2 terms found
23 Prpf3 (mouse) HNF4A
(unknown)
18395097 2 terms found
24 PRPF3 (human) HNF4A
(unknown)
18395097 6 terms found
25 SEPP1 (human) hnf4a
(unknown)
18163890 1 terms found
26 SULT2A1 (human) HNF4a
(unknown)
17687072 3 terms found
27 TASP1 (human) HNF4A
(unknown)
18395097 1 terms found
28 Tasp1 (mouse) HNF4A
(unknown)
18395097 (no terms found)
29 TGFA (human) hnf4a
(unknown)
18163890 6 terms found
30 THEM2 (human) hnf4a
(unknown)
18163890 1 terms found
31 Trpc1 (rat) HNF4a
(unknown)
18184923 11 terms found
32 UGT1A6 (human) hnf4a
(unknown)
17965524 2 terms found
33 UGT1A9 (human) hnf4a
(unknown)
17965524 2 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
  Target gene TF complex Effect References GO terms (biological process)
1 MK0390147 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
2 MK0407837 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
3 MK0401211 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
4 MK0408520 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
5 MK0410916 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
6 MK0395163 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
7 MK0420849 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
8 MK0414539 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
9 MK0407027 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
10 MK0421029 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
11 MK0394242 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
12 MK0408623 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
13 MK0392194 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
14 MK0388037 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
15 MK0386624 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
16 MK0421041 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
17 MK0406127 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
18 MK0418093 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
19 MK0410994 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
20 MK0386595 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
21 MK0397294 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
22 MK0399129 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
23 MK0386648 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
24 MK0415379 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
25 MK0417920 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
26 MK0384629 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
27 MK0414832 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
28 MK0385608 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
29 MK0392148 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
30 MK0399010 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
31 MK0387412 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
32 MK0413572 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
33 MK0383883 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
34 MK0415258 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
35 MK0413590 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
36 MK0399719 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
37 MK0383924 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
38 MK0391565 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
39 MK0385694 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
40 MK0397728 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
41 MK0419652 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
42 MK0384320 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
43 MK0415206 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
44 MK0398885 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
45 MK0386330 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
46 MK0397675 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
47 MK0407438 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
48 MK0406107 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
49 MK0415103 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
50 MK0392183 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
51 MK0415027 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
52 MK0398573 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
53 MK0413630 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
54 MK0394778 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
55 MK0417497 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
56 MK0387490 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
57 MK0385858 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
58 MK0395928 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
59 MK0397434 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
60 MK0400878 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
61 MK0413326 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
62 MK0384776 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
63 MK0405953 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
64 MK0393430 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
65 MK0415148 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
66 MK0405727 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
67 MK0416818 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
68 MK0414555 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
69 MK0396978 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
70 MK0394680 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
71 MK0385317 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
72 MK0398026 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
73 MK0393809 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
74 MK0402557 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
75 MK0388551 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
76 MK0389672 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
77 MK0383920 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
78 MK0406494 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
79 MK0409261 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
80 MK0394238 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
81 MK0419120 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
82 MK0407222 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
83 MK0405682 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
84 MK0419403 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
85 MK0412733 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
86 MK0393399 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
87 MK0407321 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
88 MK0391486 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
89 MK0387657 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
90 MK0404844 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
91 MK0409297 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
92 MK0398370 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
93 MK0419422 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
94 MK0397900 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
95 MK0396203 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
96 MK0413501 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
97 MK0386340 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
98 MK0384542 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
99 MK0415354 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
100 MK0383973 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
101 MK0413003 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
102 MK0397800 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
103 MK0387093 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
104 MK0385439 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
105 MK0391444 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
106 MK0411605 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
107 MK0413387 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
108 MK0411630 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
109 MK0383853 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
110 MK0383964 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
111 MK0389012 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
112 MK0404069 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
113 MK0394712 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
114 MK0385507 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
115 MK0399282 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
116 MK0395634 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
117 MK0419312 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
118 MK0416764 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
119 MK0398110 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
120 MK0420670 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
121 MK0407084 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
122 MK0417618 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
123 MK0407289 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
124 MK0394280 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
125 MK0384889 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
126 MK0415201 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
127 MK0396987 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
128 MK0398611 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
129 MK0402272 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
130 MK0386106 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
131 MK0419808 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
132 MK0387848 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
133 MK0395715 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
134 MK0415533 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
135 MK0399861 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
136 MK0392955 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
137 MK0417418 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
138 MK0417536 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
139 MK0398879 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
140 MK0408730 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
141 MK0407439 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
142 MK0386638 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
143 MK0400165 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
144 MK0417692 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
145 MK0421218 HNF4A_HUMAN
(unknown)
21646355 (no terms found)
146 ACADM (human) pazar HNF4A
(unknown)
8314750 9 terms found
147 Acmsd (mouse) pazar HNF4A
(unknown)
none 2 terms found
148 AFP (human) pazar HNF4A
(unknown)
15144905 9 terms found
149 AGT (human) pazar HNF4A
(unknown)
10574924 62 terms found
negative regulation of nerve growth factor receptor signaling pathway (IDA, 10406457)   smooth muscle cell differentiation   positive regulation of NF-kappaB transcription factor activity (TAS, 17906677)   positive regulation of inflammatory response (TAS, 17159080)   positive regulation of peptidyl-tyrosine phosphorylation (IDA, 15652490)   smooth muscle cell proliferation   positive regulation of fibroblast proliferation   regulation of long-term neuronal synaptic plasticity   positive regulation of organ growth   astrocyte activation   positive regulation of epidermal growth factor receptor signaling pathway (IDA, 15652490)   positive regulation of fatty acid biosynthetic process   positive regulation of MAPKKK cascade   negative regulation of neuron apoptosis   positive regulation of catalytic activity   positive regulation of apoptosis (IDA, 10406457)   hormone metabolic process   drinking behavior   regulation of cell proliferation (NAS, 17159080)   positive regulation of multicellular organism growth   low-density lipoprotein particle remodeling (NAS, 17069818)   positive regulation of NAD(P)H oxidase activity (TAS, 17159080)   positive regulation of cellular protein metabolic process (IDA, 18971559)   peristalsis   negative regulation of cell growth   extracellular matrix organization   regulation of vasoconstriction (NAS, 17159080)   response to muscle activity involved in regulation of muscle adaptation   positive regulation of phosphoinositide 3-kinase cascade (IDA, 15652490)   regulation of norepinephrine secretion   positive regulation of cholesterol esterification (IDA, 18971559)   positive regulation of macrophage derived foam cell differentiation (IC, 18971559)   positive regulation of cardiac muscle hypertrophy   positive regulation of endothelial cell migration (IDA, 15652490)   response to salt stress   response to cold   negative regulation of cell proliferation   regulation of blood pressure   establishment of blood-nerve barrier   cell-cell signaling (TAS, 8513325)   nitric oxide mediated signal transduction (TAS, 17159080)   activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger (NAS, 17159080)   G-protein signaling, coupled to cGMP nucleotide second messenger (TAS, 17159080)   G-protein coupled receptor protein signaling pathway (IDA, 10406457)   cell-matrix adhesion   cellular sodium ion homeostasis   oxygen and reactive oxygen species metabolic process (TAS, 17159080)   brain renin-angiotensin system   regulation of natriuresis (NAS, 17159080)   regulation of blood vessel size by renin-angiotensin (TAS, 10406457)   regulation of renal output by angiotensin (NAS, 17159080)   renin-angiotensin regulation of aldosterone production (NAS, 17159080)   regulation of blood volume by renin-angiotensin (NAS, 17159080)   renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure   blood vessel remodeling (TAS, 10406457)   angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure   kidney development (IMP, 16116425)   positive regulation of cytokine production (TAS, 17906677)   branching involved in ureteric bud morphogenesis   blood vessel development   regulation of cell growth (NAS, 17159080)   ovarian follicle rupture  
150 AKR1C4 (human) pazar HNF4A
(unknown)
11284743 4 terms found
151 AKR1C4 (human) pazar HNF4A_HUMAN
(unknown)
12220531 4 terms found
152 ALDH2 (human) pazar HNF4A
(unknown)
9765594 11 terms found
153 Aldob (mouse) pazar HNF4A
(unknown)
16618389 6 terms found
154 ALDOB (human) pazar HNF4A_HUMAN
(unknown)
15933209 24 terms found
155 AMBP (human) pazar HNF4A
(unknown)
7533900 8 terms found
156 APOA1 (human) pazar HNF4A
(unknown)
8464705 32 terms found
cholesterol import (IMP, 14718538)   positive regulation of transferase activity   negative regulation of hydrolase activity   positive regulation of hydrolase activity (IDA, 7638166)   protein stabilization (IDA, 17655203)   negative regulation of interleukin-1 beta secretion (IDA, 12458630)   blood vessel endothelial cell migration   reverse cholesterol transport (IMP, 15464323)   cholesterol homeostasis (IMP, 15464323)   lipoprotein biosynthetic process   high-density lipoprotein particle clearance (IC, 12651854)   high-density lipoprotein particle remodeling (IC, 4335615)   high-density lipoprotein particle assembly (IDA, 190223)   cholesterol efflux (IDA, 14703508)   phospholipid efflux (IDA, 11162594)   Cdc42 protein signal transduction (IDA, 16443932)   adrenal gland development   regulation of intestinal cholesterol absorption   cholesterol transport (IDA, 10559507)   lipid storage   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 14967812)   positive regulation of cholesterol esterification (IDA, 4335615)   cholesterol metabolic process (IMP, 15464323)   glucocorticoid metabolic process   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   lipid transport   cholesterol biosynthetic process   phosphatidylcholine biosynthetic process (IDA, 4335615)   phospholipid metabolic process   negative regulation of cytokine secretion during immune response (IDA, 12458630)   regulation of protein amino acid phosphorylation   endothelial cell proliferation  
157 APOA1 (human) pazar HNF4A_HUMAN
(unknown)
8626539 32 terms found
cholesterol import (IMP, 14718538)   positive regulation of transferase activity   negative regulation of hydrolase activity   positive regulation of hydrolase activity (IDA, 7638166)   protein stabilization (IDA, 17655203)   negative regulation of interleukin-1 beta secretion (IDA, 12458630)   blood vessel endothelial cell migration   reverse cholesterol transport (IMP, 15464323)   cholesterol homeostasis (IMP, 15464323)   lipoprotein biosynthetic process   high-density lipoprotein particle clearance (IC, 12651854)   high-density lipoprotein particle remodeling (IC, 4335615)   high-density lipoprotein particle assembly (IDA, 190223)   cholesterol efflux (IDA, 14703508)   phospholipid efflux (IDA, 11162594)   Cdc42 protein signal transduction (IDA, 16443932)   adrenal gland development   regulation of intestinal cholesterol absorption   cholesterol transport (IDA, 10559507)   lipid storage   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 14967812)   positive regulation of cholesterol esterification (IDA, 4335615)   cholesterol metabolic process (IMP, 15464323)   glucocorticoid metabolic process   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   lipid transport   cholesterol biosynthetic process   phosphatidylcholine biosynthetic process (IDA, 4335615)   phospholipid metabolic process   negative regulation of cytokine secretion during immune response (IDA, 12458630)   regulation of protein amino acid phosphorylation   endothelial cell proliferation  
158 APOA2 (human) pazar HNF4A
(unknown)
1639815 36 terms found
negative regulation of cholesterol transporter activity (IDA, 8106353)   negative regulation of cholesterol import (IDA, 10764676)   negative regulation of lipase activity (IDA, 14967812)   positive regulation of lipid catabolic process (IDA, 8640403)   response to glucocorticoid stimulus   negative regulation of lipid catabolic process (IDA, 14967812)   diacylglycerol catabolic process (IDA, 14967812)   positive regulation of interleukin-8 biosynthetic process (IDA, 11591715)   interspecies interaction between organisms   reverse cholesterol transport (IDA, 14967812)   response to estrogen stimulus   cholesterol homeostasis (IDA, 14967812)   lipoprotein metabolic process   response to drug   high-density lipoprotein particle clearance (IDA, 10764676)   high-density lipoprotein particle assembly (IDA, 218942)   low-density lipoprotein particle remodeling (IDA, 8106353)   high-density lipoprotein particle remodeling (IDA, 8106353)   triglyceride-rich lipoprotein particle remodeling (IDA, 14967812)   phospholipid efflux (IDA, 11162594)   cholesterol efflux (IDA, 11162594)   negative regulation of cholesterol transport (IMP, 8636092)   regulation of protein stability (IDA, 14967812)   organ regeneration   regulation of intestinal cholesterol absorption   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 14967812)   positive regulation of cholesterol esterification (IDA, 14967812)   response to glucose stimulus (IDA, 14988251)   phospholipid catabolic process (IDA, 14967812)   cholesterol metabolic process   lipid transport   phosphatidylcholine biosynthetic process (IDA, 14967812)   triglyceride metabolic process (TAS, 11551871)   protein folding (IDA, 14967812)   negative regulation of cytokine secretion during immune response (IDA, 12458630)   acute inflammatory response  
159 APOA4 (human) pazar HNF4A
(unknown)
7984419 27 terms found
160 APOA4 (human) pazar HNF4A_HUMAN
(unknown)
15583007 27 terms found
161 APOA5 (human) pazar HNF4A
(unknown)
16051671 18 terms found
162 APOB (human) pazar HNF4A
(unknown)
10859308 28 terms found
163 APOB (human) pazar HNF4A_HUMAN
(unknown)
15933209 28 terms found
164 Apoc2 (mouse) pazar HNF4A
(unknown)
16618389 5 terms found
165 APOC2 (human) pazar HNF4A
(unknown)
9651383 24 terms found
166 APOC3 (human) pazar HNF4A
(unknown)
2279702 28 terms found
triglyceride homeostasis (IMP, 18767813)   negative regulation of cholesterol import (IMP, 15778093)   negative regulation of lipoprotein lipase activity (IDA, 18635818)   negative regulation of lipid catabolic process (IDA, 15576844)   negative regulation of receptor-mediated endocytosis (IDA, 1917954)   negative regulation of lipid metabolic process (IDA, 182536)   negative regulation of fatty acid biosynthetic process (IDA, 11060345)   reverse cholesterol transport (IC, 15778093)   cholesterol homeostasis (IMP, 18767813)   lipoprotein metabolic process   chylomicron remnant clearance (IDA, 4020294)   very-low-density lipoprotein particle assembly (TAS, 18399797)   high-density lipoprotein particle remodeling (IMP, 17438339)   phospholipid efflux (IDA, 11162594)   cholesterol efflux (IDA, 16443932)   Cdc42 protein signal transduction (IDA, 16443932)   triglyceride catabolic process (IDA, 11060345)   negative regulation of low-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of high-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of very-low-density lipoprotein particle clearance (IDA, 1917954)   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 3973011)   negative regulation of very-low-density lipoprotein particle remodeling (IC, 18635818)   negative regulation of triglyceride catabolic process (IDA, 3973011)   cholesterol metabolic process   lipid transport   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   triglyceride metabolic process (IMP, 17142127)   triglyceride mobilization  
167 APOC3 (human) pazar HNF4A_HUMAN
(unknown)
7984419 28 terms found
triglyceride homeostasis (IMP, 18767813)   negative regulation of cholesterol import (IMP, 15778093)   negative regulation of lipoprotein lipase activity (IDA, 18635818)   negative regulation of lipid catabolic process (IDA, 15576844)   negative regulation of receptor-mediated endocytosis (IDA, 1917954)   negative regulation of lipid metabolic process (IDA, 182536)   negative regulation of fatty acid biosynthetic process (IDA, 11060345)   reverse cholesterol transport (IC, 15778093)   cholesterol homeostasis (IMP, 18767813)   lipoprotein metabolic process   chylomicron remnant clearance (IDA, 4020294)   very-low-density lipoprotein particle assembly (TAS, 18399797)   high-density lipoprotein particle remodeling (IMP, 17438339)   phospholipid efflux (IDA, 11162594)   cholesterol efflux (IDA, 16443932)   Cdc42 protein signal transduction (IDA, 16443932)   triglyceride catabolic process (IDA, 11060345)   negative regulation of low-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of high-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of very-low-density lipoprotein particle clearance (IDA, 1917954)   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 3973011)   negative regulation of very-low-density lipoprotein particle remodeling (IC, 18635818)   negative regulation of triglyceride catabolic process (IDA, 3973011)   cholesterol metabolic process   lipid transport   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   triglyceride metabolic process (IMP, 17142127)   triglyceride mobilization  
168 Aqp4 (mouse) pazar HNF4A
(unknown)
16618389 11 terms found
169 Baat (mouse) pazar HNF4A
(unknown)
14583614 4 terms found
170 Cdh1 (mouse) pazar HNF4A
(unknown)
16714383 10 terms found
171 Cdhr5 (mouse) pazar HNF4A
(unknown)
16618389 3 terms found
172 Ces2c (mouse) pazar HNF4A
(unknown)
16527247 2 terms found
173 Cldn2 (mouse) pazar HNF4A
(unknown)
16618389 1 terms found
174 Crb3 (mouse) pazar HNF4A
(unknown)
16618389 2 terms found
175 Cxadr (mouse) pazar HNF4A
(unknown)
16714383 6 terms found
176 Cyp2a4 (mouse) pazar HNF4A
(unknown)
9408084 1 terms found
177 CYP2C9 (human) pazar HNF4A
(unknown)
16540586 10 terms found
178 CYP2D6 (human) pazar HNF4A
(unknown)
8810289 15 terms found
179 Cyp3a16 (mouse) pazar HNF4A
(unknown)
11573935 1 terms found
180 Cyp3a23/3a1 (rat) pazar HNF4A
(unknown)
9917326 17 terms found
181 CYP3A4 (human) pazar HNF4A
(unknown)
12514743 14 terms found
182 CYP3A4 (human) pazar HNF4A_HUMAN
(unknown)
14742674 14 terms found
183 Cyp4a1 (rat) pazar HNF4A
(unknown)
1605646 7 terms found
184 CYP7A1 (human) pazar HNF4A
(unknown)
9799805 10 terms found
185 CYP7A1 (human) pazar HNF4A_HUMAN
(unknown)
15933209 10 terms found
186 CYP7A1 (human) pazar HNF4A_HUMAN
(unknown)
11544200 10 terms found
187 CYP8B1 (human) pazar HNF4A
(unknown)
11535594 1 terms found
188 Cyp8b1 (rat) pazar HNF4A
(unknown)
11574686 (no terms found)
189 CYP8B1 (human) pazar HNF4A_HUMAN
(unknown)
15933209 1 terms found
190 F10 (human) pazar HNF4A
(unknown)
1313796 5 terms found
191 F10 (human) pazar HNF4A_HUMAN
(unknown)
11159521 5 terms found
192 F2 (human) pazar HNF4A
(unknown)
12911579 23 terms found
193 F7 (mouse) pazar HNF4A
(unknown)
9442072 5 terms found
194 F7 (human) pazar HNF4A
(unknown)
8978290 18 terms found
195 F9 (human) pazar HNF4A
(unknown)
8562402 3 terms found
196 Fabp2 (rat) pazar HNF4A
(unknown)
8505324 5 terms found
197 FMO1 (human) pazar HNF4A
(unknown)
11723251 6 terms found
198 G6PC (human) pazar HNF4A
(unknown)
12651943 12 terms found
199 G6PC (human) pazar HNF4A_HUMAN
(unknown)
15933209 12 terms found
200 G6PC (human) pazar HNF4A_HUMAN
(unknown)
11544200 12 terms found
201 Gatm (mouse) pazar HNF4A
(unknown)
16618389 5 terms found
202 Gck (rat) pazar HNF4A
(unknown)
11950391 35 terms found
detection of glucose (IMP, 16443775)   detection of glucose   detection of glucose   regulation of insulin secretion   glucose 6-phosphate metabolic process (IDA, 15138155)   carbohydrate phosphorylation (IDA, 15138155)   carbohydrate phosphorylation   positive regulation of glycolysis (IDA, 17553851)   positive regulation of glycogen biosynthetic process   positive regulation of glycogen biosynthetic process   negative regulation of gluconeogenesis   negative regulation of gluconeogenesis   regulation of potassium ion transport   glucose homeostasis   glucose homeostasis   glucose homeostasis (IMP, 18292346)   positive regulation of phosphorylation (IDA, 17553851)   positive regulation of insulin secretion   cellular response to glucose starvation (IMP, 18292346)   negative regulation of epinephrine secretion (IMP, 18292346)   positive regulation of insulin secretion   positive regulation of insulin secretion (IDA, 17028192)   second-messenger-mediated signaling (IDA, 11250924)   response to glucose stimulus (IEP, 12086933)   elevation of cytosolic calcium ion concentration (IDA, 17360975)   glucose metabolic process   NADP metabolic process   glycolysis (IDA, 4273555)   glucose metabolic process (IDA, 17553851)   carbohydrate metabolic process   glycogen biosynthetic process (IDA, 17028192)   fructose 2,6-bisphosphate metabolic process (IDA, 17553851)   cellular glucose homeostasis (TAS, 11250924)   cellular glucose homeostasis (IMP, 16443775)   cellular glucose homeostasis  
203 Gjb1 (mouse) pazar HNF4A
(unknown)
16714383 3 terms found
204 Gpld1 (mouse) pazar HNF4A
(unknown)
16714383 1 terms found
205 GUCY2C (human) pazar HNF4A
(unknown)
10070050 6 terms found
206 HNF1A (human) pazar HNF4A
(unknown)
9313764 29 terms found
207 Hnf1b (mouse) pazar HNF4A
(unknown)
8622679 26 terms found
208 Hnf4a (mouse) pazar HNF4A
(unknown)
11522818 31 terms found
SMAD protein signal transduction (IDA, 9420335)   regulation of insulin secretion (IMP, 15761495)   negative regulation of peptidyl-tyrosine phosphorylation   positive regulation of transcription from RNA polymerase II promoter (ISO, 7615825)   positive regulation of transcription from RNA polymerase II promoter (IMP, 16537911)   positive regulation of transcription from RNA polymerase II promoter (IGI, 17636037)   positive regulation of transcription from RNA polymerase II promoter (IDA, 16527247)   negative regulation of mitotic cell cycle   positive regulation of fatty acid biosynthetic process   positive regulation of gluconeogenesis   regulation of transcription (IMP, 9053305)   regulation of transcription   cell-cell junction organization   negative regulation of transcription factor activity   glucose homeostasis (IMP, 15761495)   negative regulation of tyrosine phosphorylation of Stat5 protein   negative regulation of protein import into nucleus, translocation   cell differentiation   regulation of microvillus assembly   positive regulation of gene-specific transcription from RNA polymerase II promoter (IDA, 15761495)   regulation of gastrulation (IMP, 7958910)   response to glucose stimulus   response to glucose stimulus (IMP, 15761495)   negative regulation of cell proliferation   sex differentiation (IMP, 17412818)   acyl-CoA metabolic process   establishment of tissue polarity   regulation of transcription, DNA-dependent   lipid metabolic process (IMP, 16498401)   transcription   regulation of transcription, DNA-dependent  
209 Ins1 (rat) pazar HNF4A
(unknown)
11994285 6 terms found
210 Kcnj11 (mouse) pazar HNF4A
(unknown)
15761495 5 terms found
211 LCT (human) pazar NUCLEAR EXTRACTCACO-2
HNF4A_HUMAN
(unknown)
16301215 12 terms found
212 Lgals9 (mouse) pazar HNF4A
(unknown)
16714383 1 terms found
213 MST1 (human) pazar HNF4A
(unknown)
8621550 3 terms found
214 MTTP (human) pazar HNF4A
(unknown)
7961826 2 terms found
215 Neu3 (mouse) pazar HNF4A
(unknown)
16618389 2 terms found
216 Npnt (mouse) pazar HNF4A
(unknown)
16714383 10 terms found
217 NR0B2 (human) pazar HNF4A
(unknown)
11679424 7 terms found
218 Nr1i3 (mouse) pazar HNF4A
(unknown)
16825189 5 terms found
219 Onecut1 (rat) pazar HNF4A
(unknown)
10674400 20 terms found
220 Otc (rat) pazar HNF4A
(unknown)
8496174 6 terms found
221 PAK7 (human) pazar HNF4A
(unknown)
15615695 2 terms found
222 Pck1 (rat) pazar HNF4A
(unknown)
1333043 14 terms found
223 Pklr (rat) pazar HNF4A
(unknown)
8246989 16 terms found
224 Pkp2 (mouse) pazar HNF4A
(unknown)
16714383 2 terms found
225 PPARA (human) pazar HNF4A
(unknown)
11981036 23 terms found
226 Prodh2 (mouse) pazar HNF4A
(unknown)
15581617 5 terms found
227 Rbp2 (rat) pazar HNF4A
(unknown)
8288643 2 terms found
228 RPS6KA6 (human) pazar HNF4A
(unknown)
15615695 4 terms found
229 Saa1 (mouse) pazar HNF4A
(unknown)
16618389 1 terms found
230 SERPINC1 (human) pazar HNF4A
(unknown)
7758957 3 terms found
231 SHBG (human) pazar HNF4A
(unknown)
9852068 2 terms found
232 SLC22A1 (human) pazar HNF4A
(unknown)
16436500 2 terms found
233 Slc27a5 (mouse) pazar HNF4A
(unknown)
14583614 10 terms found
234 Slc39a4 (mouse) pazar HNF4A
(unknown)
16618389 7 terms found
235 Tat (rat) pazar HNF4A
(unknown)
8100067 13 terms found
236 Trf (mouse) pazar HNF4A
(unknown)
8226864 8 terms found
237 Ttr (mouse) pazar HNF4A
(unknown)
2279702 1 terms found
238 TTR (human) pazar HNF4A_HUMAN
(unknown)
11544200 1 terms found
239 Vtn (mouse) pazar HNF4A
(unknown)
16714383 5 terms found